Synthetic RNA silencing in bacteria – antimicrobial discovery and resistance breaking
Liam Good1 and James E. M. Stach2*
1 Department of Pathology and Infectious Diseases, Royal Veterinary College, University of London, London, UK
2 School of Biology, Newcastle University, Newcastle upon Tyne, UK
The increasing incidence and prevalence of antibiotic resistance in bacteria threatens the “antibiotic miracle.” Conventional antimicrobial drug development has failed to replace the armamentarium needed to combat this problem, and novel solutions are urgently required. Here we review both natural and synthetic RNA silencing and its potential to provide new antibacterials through improved target selection, evaluation, and screening. Furthermore, we focus on synthetic RNA silencers as a novel class of antibacterials and review their unique properties.
Front. Microbiol., 12 September 2011 | doi: 10.3389/fmicb.2011.00185